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Interested in Participating in Our Research Studies?

The Microvascular Physiology Lab relies on research volunteers who participate in our studies. 

Ongoing Research Studies

Sensitivity of Angiotensin II Type II Receptors in Women Following Preeclampsia

The purpose of this study is to determine the mechanisms contributing to lasting blood vessel function damage caused by reduced endothelial function in women who have had preeclampsia compared to women who had a healthy pregnancy. Identification of these mechanisms and treatment strategies may lead to better clinical management of cardiovascular disease risk in these women.

Women who had preeclampsia or did not have preeclampsia and were pregnant within the past 5 years are eligible to participate in this study. For more information contact Kelsey Schwartz: kelsey-schwartz@uiowa.edu.

https://clinicaltrials.uihealthcare.org/studies/sensitivity-angiotensin-ii-type-ii-receptors-women-following-preeclampsia

Protective Mechanisms of Prenatal Aspirin Therapy on Maternal Vascular Dysfunction Following Preeclampsia

Preeclampsia may cause harmful changes to blood vessels and lead to cardiovascular disease. These changes affect how the body controls blood flow. The purpose of this study is to understand how a history of preeclampsia affects blood vessel function and how aspirin use during pregnancy changes these effects. 

Women who had preeclampsia or did not have preeclampsia and were pregnant within the past 5 years are eligible to participate in this study. For more information contact Kaila Brustkern: kaila-brustkern@uiowa.edu, (319)467-3096.

https://clinicaltrials.uihealthcare.org/studies/protective-mechanisms-prenatal-aspirin-therapy-maternal-vascular-dysfunction-following 

Mechanisms of Vascular Endothelial Dysfunction in Chronic E-cigarette Users

The purpose of this study is to determine whether chronic e-cigarette use (vaping) leads to blood vessel dysfunction in healthy young adults. 

Men and women, ages 18-24, who use e-cigarettes and those who do not are eligible to participate in this study. For more information contact Kaila Brustkern: kaila-brustkern@uiowa.edu, (319)467-3096.

https://clinicaltrials.uihealthcare.org/studies/mechanisms-vascular-endothelial-dysfunction-chronic-e-cigarette-users

Role of Oxidative Stress in Microvascular Dysfunction Following Gestational Diabetes

The purpose of this study is to determine whether there is lasting blood vessel dysfunction after a pregnancy complicated by gestational diabetes, and if so, what the underlying cause of that dysfunction might be. Identification of this dysfunction and its cause(s) may lead to better clinical management and cardiovascular health outcomes in women who have had gestational diabetes. 

Women who had gestational diabetes or did not have gestational diabetes and were pregnant in the past 5 years are eligible to participate in this study. For more information contact Kaila Brustkern: kaila-brustkern@uiowa.edu, (319)467-3096.

https://clinicaltrials.uihealthcare.org/studies/role-oxidative-stress-microvascular-dysfunction-following-gestational-diabetes

Angiotensin II Receptor Inhibition to Improve Microvascular Function in Women who have had Preeclampsia

The purpose of this study is to determine the mechanisms contributing to blood vessel damage and chronic inflammation, and to test whether taking a medication that blocks angiotensin II receptors (losartan) decreases these negative effects in women who have had preeclampsia. Identification of these mechanisms and treatment strategies may lead to better clinical management of cardiovascular disease risk in these women.

Women who had preeclampsia and were pregnant within the past 2 years are eligible to participate in this study. For more information please contact Dr. Anna Stanhewicz: anna-stanhewicz@uiowa.edu, (319)467-1732

https://clinicaltrials.uihealthcare.org/studies/angiotensin-ii-receptor-inhibition-improve-microvascular-function-women-who-have-had