About: The Microvascular Physiology Lab studies the human cutaneous circulation to understand how blood vessels function in health and disease. We are particularly interested in understanding the mechanisms that control blood vessel function and how those mechanisms change in people who have cardiovascular or metabolic disease, and what the best intervention strategies are to prevent or reverse disease in these patients.
Our current focus is studying the mechanisms that contribute to vascular dysfunction in women who have had preeclampsia during pregnancy. Women who have preeclampsia during pregnancy are more likely to develop cardiovascular disease later in life. Preeclampsia is a hypertensive disorder of pregnancy that resolves after delivery, but despite this remission of symptoms women who have a history of preeclampsia are 4 times more likely to develop cardiovascular disease. We are working to understand the cellular mechanisms that are changed during a preeclamptic pregnancy and to identify physiological and pharmacological interventions that treat these changes.